England head coach Eddie Jones on Owen Farrell's knock: "My dog was running around and he ran into it. Annie is a pretty tricky runner and sometimes she gets off the leash".
Youngs, Joseph and Nowell take the places of Danny Care, Ben Te'o and Jonny May while Billy and Mako Vunipola have been listed as replacements by Jones, who will want England to improve on their largely disappointing performance against Italy last time out.
Bath winger Watson makes the bench for his first global in eight months and Joe Marler will lead the side out on his 50th cap.
Billy Vunipola has been named on the bench for England's titanic Six Nations clash against Scotland on Saturday after making a rapid recovery from a knee ligament injury.
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Vunipola has played just 72 minutes for Saracens since suffering a knee injury in November and despite returning to the England camp this week, Jones has opted against naming him in the starting XV.
When it was pointed out that his answers could be construed as ambiguous, Jones added: "Yeah, but I think he'll be all right, is that okay?"
"This is the 124th Calcutta Cup and I feel humbled and honoured to be part of such an historic rugby occasion, it's the oldest global fixture and means a lot to both countries".
"It's the oldest worldwide fixture and means a lot to both countries".
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I thought we dealt with it fantastically well.
Scotland find themselves in the unusual position of chasing down a Triple Crown heading into the penultimate round of Six Nations fixtures this weekend.
Eddie Jones' unbeaten side produced their worst half under the Australian last time before finally seeing off Italy 36-15 and there's little doubt that unless they up their game considerably could come unstuck against the Scots, but I simply can't see it.
Unfortunately for the visitors, their scrum has really struggled, even in their victories, and with England's pack looking strong and settled, the odds remain very much in favour of another home win.
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England: Mike Brown, Jack Nowell, Jonathan Joseph, Owen Farrell, Elliot Daly, George Ford, Ben Youngs; Nathan Hughes, James Haskell, Maro Itoje, Courtney Lawes, Joe Launchbury, Dan Cole, Dylan Hartley (captain), Joe Marler.